PTMVision

PTMVision enables interactive exploration and contextual analysis of post-translational modifications (PTMs) identified in mass spectrometry-based proteomics experiments.

Key Features:

• Multi-level PTM visualization: The tool visualizes the PTM landscape from different angles and at different levels, including 3D structures, contact maps, UniMod classification summaries, and site-specific overviews.
• Modification site analysis: The tool analyzes modification sites of proteins within relevant biological context.
• Open modification search compatibility: The tool supports PTMs identified through open modification search strategies that reveal hundreds to thousands of distinct modifications in biological samples.

Scientific Applications:

• PTM landscape investigation: The tool facilitates comprehensive investigation of the PTM landscape from mass spectrometry data.
• Protein modification examination: The tool enables thorough examination of modifications on proteins of interest from acquired mass spectrometry data.

Methodology:

PTMVision processes PTM identifications from mass spectrometry-based proteomics experiments using open modification search strategies.