HW_TEST

HW_TEST tests Hardy–Weinberg equilibrium using autosomal genotype data to assess whether observed genotype frequencies conform to Hardy–Weinberg proportions.

Key Features:

• Multiallelic data compatibility: Supports genotype data from autosomal markers with 2 to 12 alleles.
• Diverse testing methods: Implements parametric, nonparametric, and exact bootstrap procedures to test the null hypothesis of Hardy–Weinberg proportions.
• Result reporting: Generates results reported in formats suitable for downstream statistical analysis and reporting.

Scientific Applications:

• Population genetics: Evaluates conformity to Hardy–Weinberg expectations and identifies deviations consistent with selection, population structure, non-random mating, mutation, migration, or genetic drift.
• Genotyping quality control: Used for quality control and biological interpretation in genotyping studies.

Methodology:

Users provide genotype data for autosomal markers (including multiallelic markers); the software applies parametric, nonparametric, and bootstrap-based procedures to test the null hypothesis of Hardy–Weinberg proportions; results are reported for downstream analysis.