MetaTropismDB

MetaTropismDB aggregates and annotates experimental conditions and outcomes from xenograft studies to provide a curated resource for analyzing organ-specific metastasis.

Key Features:

• Comprehensive Data Collection: Annotations extracted from 513 published xenograft studies detailing experimental conditions and outcomes.
• Experimental Details: Records include inoculated human cancer cell lines, mouse models, injection methods, sites of metastasis, organs not colonized, metastasis rate, latency time, overall survival rates, and genes implicated in organotropic metastases.
• Gene Involvement: Contains curated data on 296 genes associated with organ-specific metastasis.
• Research Facilitation: Hand-curated, study-level data enable cross-study comparison of organotropism results and support design of experiments to identify tumor molecular signatures that determine metastatic sites.

Scientific Applications:

• Mechanistic Studies: Support investigation of molecular determinants and pathways underlying organ-specific metastasis using xenograft-derived annotations.
• Comparative Analysis and Hypothesis Generation: Enable cross-study comparisons and generation of hypotheses about genes and experimental conditions that influence metastatic tropism.
• Therapeutic Target Identification: Assist in prioritizing candidate therapeutic targets and genetic factors that shape metastatic patterns.

Methodology:

Data were obtained by systematic literature review and manual curation of xenograft experiments, with each experiment's conditions and outcomes annotated.