COVID-ONE-humoral immune

COVID-ONE-humoral immune provides integrated IgG and IgM antibody profiling linked to clinical parameters for analysis of SARS-CoV-2 humoral immune responses.

Key Features:

• Extensive dataset: IgG and IgM immune responses to 21 of the 28 known SARS-CoV-2 proteins and to 197 spike protein peptides, measured across 2,360 COVID-19 samples from 783 patients.
• Clinical parameters integration: Integration of 96 clinical parameters per sample with comprehensive patient metadata to enable correlation analyses.
• Sample stratification: Support for defining and stratifying sample cohorts across multiple clinical and immunological parameters.
• Analysis pipeline for group comparisons: Built-in pipeline for single or paired group comparative analyses and generation of comprehensive analysis reports.

Scientific Applications:

• Immune-response heterogeneity: Characterize inter-patient variability in IgG and IgM antibody responses to SARS-CoV-2.
• Disease progression and recovery: Correlate antibody profiles with clinical parameters to investigate disease progression and recovery mechanisms.
• Therapeutic and vaccine research: Identify immune response patterns relevant to therapeutic target discovery and vaccine development.

Methodology:

Integration of IgG/IgM profiling with 96 clinical parameters and execution of single or paired group comparative analyses via an internal analysis pipeline.