DRAVP

DRAVP provides a curated database of antiviral peptides and proteins to support discovery, characterization, and structure-guided design of antiviral agents.

Key Features:

• Extensive Data Repository: DRAVP consolidates general details, antiviral activity profiles, structural data, physicochemical properties, and literature references for antiviral peptides and proteins.
• Structural Predictions with AlphaFold: DRAVP uses AlphaFold to predict structures of antiviral peptides and proteins that lack experimentally determined structures.
• Coverage of Natural and Synthetic Antivirals: DRAVP includes naturally occurring antiviral proteins (e.g., interferons) and synthetic antimicrobial peptides (e.g., defensins), with annotations on antiviral effects and immune-modulatory capacity.

Scientific Applications:

• Antiviral Candidate Identification: Use curated activity profiles and physicochemical properties to identify and prioritize antiviral peptide and protein candidates.
• Structure-Guided Design: Employ AlphaFold-predicted and curated structural data to model peptide–protein interactions and guide rational design of improved compounds.
• Mechanistic and Interdisciplinary Studies: Support analysis of mechanisms of action and studies integrating bioinformatics, structural biology, and pharmacology.

Methodology:

Consolidation of literature-derived annotations and use of AlphaFold for structure prediction of antiviral peptides and proteins.