purgeR

purgeR estimates inbreeding and purging parameters from pedigreed populations to quantify Wright's, partial and ancestral inbreeding coefficients and purged inbreeding and opportunity of purging for analyses of inbreeding depression and purging.

Key Features:

• Inbreeding Coefficient Estimation: Estimates Wright's, partial, and ancestral inbreeding coefficients from pedigreed populations.
• Purging Parameter Calculation: Calculates purged inbreeding and opportunity of purging coefficients to quantify the extent of removal of deleterious alleles and mitigation of inbreeding depression.
• Population Demographic Contextualization: Provides functions to estimate population parameters to contextualize inbreeding and purging within a population's demographic history.
• Pedigree Analysis: Supports analysis of complex pedigrees to assess implications for genetic diversity and fitness.

Scientific Applications:

• Evolutionary Biology: Enables study of fitness and inbreeding load evolution in small populations.
• Conservation Genetics: Assesses risks from inbreeding depression and the potential for genetic recovery via purging in endangered populations.
• Population Genetics Research: Supports detailed analyses of pedigreed populations to investigate genetic diversity, inbreeding dynamics, and purging effects.

Methodology:

Implemented as an R package, purgeR integrates statistical methods to estimate inbreeding coefficients (Wright's, partial, ancestral), purged inbreeding and opportunity of purging coefficients, and population parameter estimators from pedigreed data.