pwrEWAS

pwrEWAS estimates power for two-group comparisons of DNA methylation (DNAm).

Key Features:

• Semi-parametric Simulation-Based Approach: Generates DNAm data from beta-distributions using CpG-specific means and variances.
• Customizable Parameters: Allows specification of tissue type, sample size, number of differentially methylated CpGs, effect sizes, target FDR, and statistical methods.
• Comprehensive Output Metrics: Reports marginal power, type I error rate, FDR, and false discovery cost (FDC).

Scientific Applications:

• EWAS Design: Helps researchers determine appropriate sample sizes for desired statistical power.

Methodology:

Simulates DNAm data from beta distributions using CpG-specific means and variances derived from existing datasets.