PXStools

PXStools performs exposure-wide association studies and derives polyexposure risk scores using regression modeling, including hierarchical lasso, to evaluate the effects of multiple environmental exposures on phenotypes.

Key Features:

• Exposure-Wide Association Studies: Conduct comprehensive analysis of multiple environmental exposures and phenotypes.
• Polyexposure Risk Scores: Derive and validate risk scores using advanced regression techniques and account for exposure interactions.
• Model Comparison: Compare models with and without polyexposures to assess predictive value and model goodness-of-fit.

Scientific Applications:

• Epidemiological Studies: Investigate the impact of multiple environmental exposures on health outcomes.

Methodology:

Apply regression modeling techniques, including hierarchical lasso, to derive and validate polyexposure risk scores, account for exposure interactions, and compare models with and without polyexposures to assess predictive value and model goodness-of-fit.