PyToxo

PyToxo generates penetrance tables from any-order epistasis models to support analysis of high-order genetic interactions influencing complex phenotypes.

Key Features:

• High-Order Epistasis Modeling: Generates penetrance tables for complex interactions involving multiple genetic loci from any-order epistasis models.
• Precision and Efficiency: Produces high-precision numerical outputs suitable for computational evaluation of epistatic models.
• Realistic Parameter Handling: Supports specification of realistic penetrance and heritability values for epistasis studies.

Scientific Applications:

• Algorithm Evaluation: Provides penetrance tables for benchmarking and evaluating methods that detect high-order epistatic interactions.
• Complex Disease Genetics: Enables investigation of genetic architectures underlying multifactorial traits and disorders by specifying interaction models and penetrance patterns.

Methodology:

Generates penetrance tables from any-order epistasis models while supporting realistic penetrance and heritability parameters and producing high-precision results.