QSHGM

QSHGM catalogs 28,567 nonredundant quorum sensing synthases and receptors across 818 distinct human gut microbes to enable analysis and prediction of QS-based microbial communication networks.

Key Features:

• Extensive QS Repository: Contains 28,567 nonredundant entries of quorum sensing synthases and receptors derived from 818 distinct gut microbes.
• Systematic Workflow: Built using a three-module systematic workflow that employs machine learning-based ensemble classifiers to collect reported QS entries, expand the repository, and mine new potential QS proteins.
• Predictive Capabilities: Enables prediction and construction of detailed QS communication networks for analysis of QS-based microbial interactions in the human gut microbiota.
• Research Integration: Provides data to support construction of knowledge maps and studies on microbial interactions with implications for gut health and therapeutic strategies for gut diseases.

Scientific Applications:

• Knowledge mapping: Supports building knowledge maps of the human gut microbiota based on quorum sensing interactions.
• Interaction prediction and network analysis: Facilitates prediction and analysis of QS-mediated microbial interactions and communication networks.
• Therapeutic hypothesis generation: Aids identification of QS-related targets and hypotheses relevant to gut health and interventions for gut diseases.

Methodology:

Integration of reported QS entries with a three-module systematic workflow that uses machine learning-based ensemble classifiers to expand the repository and mine new potential QS proteins.