quickLD

QuickLD: High-Performance Linkage Disequilibrium Computation

QuickLD computes linkage disequilibrium (LD) by quantifying non-random associations of alleles at different loci in population-scale genetic datasets.

Key Features:

• Efficient LD Calculation: Computes LD metrics, including D' and r², using optimized statistical algorithms.
• Scalability: Processes large-scale genomic datasets for genome-wide analyses.

Scientific Applications:

• Genome-Wide Association Studies (GWAS): Quantifies LD patterns across loci to support association mapping and population genetic analyses.

Methodology:

Applies population genetics–based statistical algorithms to estimate LD metrics (D' and r²) from haplotype frequency data, maintaining accuracy in the presence of missing data and complex population structures.