rain

The software tool "RAIN" addresses challenges in detecting and assessing the significance of biological rhythms within large datasets. Traditional Fourier-based methods face limitations due to the unpredictable nature of experimental and biological noise. While robust nonparametric methods exist, they are often restricted to specific waveforms. RAIN is a robust nonparametric method capable of detecting rhythms with prespecified periods in biological data, accommodating arbitrary waveforms.