RATEmiRs

RATEmiRs: Tissue-Specific and Enriched miRNA Expression Database for Rat Tissues

RATEmiRs catalogs and analyzes microRNA (miRNA) expression across 21 and 23 tissues from male and female Sprague-Dawley rats, enabling identification of tissue-enriched (TE), tissue-specific (TS), and organ-specific (OS) miRNAs through comparative expression analysis.

Key Features:

• Tissue-Specific and Enriched miRNA Cataloging: Classifies TE, TS, and OS miRNAs by comparing expression levels across multiple rat tissues and organs.
• Data-Driven Pipelines: Implements automated pipelines for systematic detection of TE and TS miRNAs from sequencing datasets.
• Organ-Specific Pipelines: Identifies miRNAs unique to defined tissue sets representing specific organs.
• Comparative Cross-Species Analysis: Compares rat and human miRNA expression profiles to support translational studies.

Scientific Applications:

• Biomarker Discovery and Tissue-Specific Regulation: Supports identification of miRNA biomarkers for organ damage and disease and investigation of tissue-specific regulatory mechanisms.
• Translational Research: Facilitates cross-species comparison of rat and human miRNA expression patterns.

Methodology:

miRNAs were sequenced from multiple rat tissues and analyzed using bioinformatic pipelines to quantify expression and classify miRNAs as TE, TS, or OS based on comparative expression patterns across tissues and organs.