RBP2GO

RBP2GO aggregates proteome-wide datasets from 53 studies across 13 species (105 datasets) to catalog 22,552 RNA-binding protein (RBP) candidates and integrate their interaction partners and functional annotations for comparative analysis.

Key Features:

• Dataset aggregation: Aggregates proteome-wide datasets from 53 studies across 13 species comprising 105 datasets.
• RBP candidate compilation: Identifies and catalogs 22,552 RBP candidates.
• Interaction and functional annotation integration: Integrates data on RBP interaction partners and annotations of biological processes, molecular functions, and cellular compartments.
• RBP scoring system: Implements an RBP scoring system to assess RBP candidates.
• Search modes: Supports forward and reverse searches to link biological functions or processes with corresponding RBPs.
• Comparative screening: Enables cross-study and cross-species comparison and screening of RBP-related data.

Scientific Applications:

• RBP role exploration: Exploring multifaceted roles of RBPs in cellular pathways and functions and their implications for health and disease.
• Functional association mapping: Connecting specific biological processes, molecular functions, or cellular compartments with corresponding RBPs through forward and reverse searches.
• Cross-study and cross-species analysis: Screening and comparative analysis of RBP datasets across 13 species and multiple studies.

Methodology:

Aggregation of proteome-wide datasets from 53 studies across 13 species (105 datasets) and integration of RBP interaction partners with annotations of biological processes, molecular functions, and cellular compartments; implementation of an RBP scoring system and support for forward and reverse searches.