RBPWorld

RBPWorld explores functions and disease associations of RNA-binding proteins across species by leveraging 998 RNA-binding domains and 87 RNA-binding Proteome datasets.

Key Features:

• RBP Identification: Identifies 1,393,413 RBPs from 445 species, including 3030 human RBPs (hRBPs).
• RNA Target Analysis: Includes primary RNA targets of diverse hRBPs derived from 1515 crosslinking immunoprecipitation-seq datasets.
• Regulatory Pathway Analysis: Provides potential downstream regulatory pathways and alternative splicing patterns governed by various hRBPs.
• Multi-functional RBP Identification: Systematically identifies 929 RBPs with multi-functions, including acting as metabolic enzymes and transcription factors.
• Disease Association Data: Includes 838 disease-associated hRBPs and 970 hRBPs that interact with 12 disease-causing RNA viruses.
• Transcriptomic Data Integration: Incorporates analyses of 616 RNA-seq datasets from cells with hRBP gene knockdown or knockout.

Scientific Applications:

• RBP Function Investigation: Facilitates investigation of RBP functions across physiological and pathological processes.
• Disease Research: Enables exploration of regulatory roles of hRBPs within the context of diseases and viral interactions.
• Alternative Splicing Studies: Supports analysis of alternative splicing patterns governed by various hRBPs.
• Cross-species Comparative Analysis: Advances understanding of biological roles of RBPs across different species.

Methodology:

RBPWorld was developed by updating EuRBPDB and leveraging 998 RNA-binding domains and 87 RNA-binding Proteome datasets.