RCDdb

RCDdb compiles manually curated marker gene annotations across 15 regulated cell death types to support mechanistic studies and therapeutic research into cell death-associated diseases.

Key Features:

• Comprehensive RCD annotations: The database contains 3090 marker gene annotations associated with 15 RCD types compiled from 2180 relevant articles.
• Multi-dimensional gene annotation: Marker genes are annotated with respect to diseases, drugs, pathways, proteins, and gene expressions.
• Visualization capabilities: The platform provides 49 diverse visualization methods to present annotation information.
• Online analysis tools: Three online analysis tools identify and analyze RCD-related features within user-submitted data.

Scientific Applications:

• RCD mechanism research: Researchers use the resource to study regulatory mechanisms governing the development and homeostasis of multicellular organisms through regulated cell death.
• Disease-associated cell death studies: The database supports investigation of diseases associated with cell death, including cancer and neurodegenerative diseases.
• Therapeutic strategy development: The resource aids in developing novel therapeutic strategies against RCD-related diseases by providing comprehensive annotation and analytical capabilities.
• RCD feature identification: Users can identify and analyze RCD-related features within their own submitted datasets using the integrated analysis tools.

Methodology:

Manual curation of 3090 marker gene annotations from 2180 articles across 15 RCD types.