Reactome Small Molecule Search

Reactome Small Molecule Search enables exploration of small molecules and their roles in Reactome biological pathways by integrating ChEBI annotations within the Reactome Knowledgebase's consistent data model.

Key Features:

• Pathway diagram viewer: Multi-scale visualization that supports zooming from complete reaction networks to individual reactions.
• Analysis performance for genome-wide datasets: Generates results for genome-wide expression datasets within seconds, enabling rapid analysis of large-scale data.
• RESTful API access: Provides programmatic access to the analysis module via a RESTful interface.
• Search functionality: Supports auto-completion and faceted search to refine small-molecule queries.
• Genome-wide pathway overview: Maps analysis results onto a genome-wide Reactome pathway hierarchy for integrated visualization.
• Data integration and data model: Integrates annotations from ChEBI and organizes molecular transformations within Reactome's consistent data model.

Scientific Applications:

• Discovery of functional relationships: Identification of unexpected functional relationships in gene expression pattern surveys and somatic mutation catalogues from tumor cells.
• Small-molecule pathway analysis: Exploration of small molecules within processes such as signal transduction, transport, DNA replication, and metabolism.
• Genome-wide data mapping: Contextualization of genome-wide expression and other large-scale datasets within the Reactome pathway hierarchy.

Methodology:

Integrates ChEBI data into the Reactome Knowledgebase's consistent data model and applies efficient search algorithms, advanced visualization techniques, and a RESTful interface to analyze and map genome-wide datasets onto the Reactome pathway hierarchy.