readat

readat imports and parses SomaLogic ADAT files to convert SOMAscan protein abundance measurements, including measurements of over 1,300 proteins from plasma and serum, into structured R data frames for downstream proteomics analysis.

Key Features:

• Data Importation: Imports and parses SomaLogic ADAT files produced by the SOMAscan assay to capture protein abundance measurements.
• Data Transformation: Transforms raw assay data into formats suitable for downstream analysis and integration with bioinformatics workflows.
• Data Annotation: Provides annotation functionality to link protein abundance data to relevant biological information.
• Integration with Bioconductor and R Workflows: Produces R data structures compatible with Bioconductor and standard R packages to enable downstream analyses.

Scientific Applications:

• Proteomics research: Enables comprehensive analysis of protein expression profiles from SOMAscan assays.
• Biomarker discovery: Facilitates investigations into disease biomarkers using plasma and serum protein measurements.
• Physiological response analysis: Supports analysis of protein-level changes associated with physiological states and responses.
• Molecular mechanism investigation: Supports studies of molecular mechanisms underlying health and disease using SOMAscan-derived protein data.

Methodology:

Parses the proprietary SomaLogic ADAT text format and converts the contents into structured R data frames, enabling interoperability with Bioconductor packages.