Recode

Recode catalogs the Recode2 database of approximately 1500 genes that employ translational recoding events, including programmed ribosomal frameshifting, stop codon readthrough, selenocysteine insertion, and translational bypassing (hopping), to support annotation and analysis of non-standard translation.

Key Features:

• Database Content: Recode2 contains data on approximately 1500 genes known to utilize various forms of translational recoding.
• Types of Recoding Events: The database documents programmed ribosomal frameshifting, stop codon readthrough, selenocysteine insertion, and translational bypassing (hopping) as non-standard interpretations of the genetic code during protein synthesis.
• Search and Annotated Sequence Elements: The resource supports complex search queries and provides annotated sequence elements for detailed examination of recoded genes.

Scientific Applications:

• Gene Annotation: Facilitates more accurate annotation of genes that utilize non-standard translation processes.
• Training Data for Gene-Annotation Software: Provides curated cases of recoding for use in development of gene-annotation software.
• Educational Reference: Serves as a reference for molecular biology education on translational recoding phenomena.

Methodology:

Recode2 aggregates reported cases of translational recoding from scientific literature and other sources to compile the database.