recombinase

recombinase provides an integrated resource linked to Mouse Genome Informatics and the literature (PMID: 34482425) for selection and characterization of recombinase alleles and transgenes to enable spatio-temporal control of gene disruption or transgene expression.

Key Features:

• Integration of Comprehensive Data: Aggregates data from Mouse Genome Informatics, scientific literature, direct submissions from researchers, and major projects developing new recombinase lines.
• Detailed Characterization: Supplies detailed characterization of recombinase expression and activity for selecting alleles or transgenes suitable for specific tissues and developmental stages.
• Search Functionality: Supports searches by recombinase activity or specific gene drivers and returns summaries plus matrix comparisons of gene expression and recombinase activity.
• Comprehensive Data Presentation: Presents generation details, a recombinase activity grid, and phenotype annotations linked to each allele or transgene.
• Future Enhancements: Plans to add cell type-based activity annotations to increase specificity of activity descriptions.

Scientific Applications:

• Conditional gene knockout or activation: Enables selection of recombinase alleles and transgenes for spatially and temporally controlled gene inactivation or activation experiments.
• Tissue- and developmental-stage-specific functional analysis: Facilitates investigation of gene function in defined tissues or developmental stages using characterized recombinase lines.
• In vivo recombination study design and interpretation: Supports choice of appropriate recombinase tools and interpretation of resulting phenotypes in animal models.

Methodology:

Integrates and compiles information from scientific literature, direct researcher submissions, Mouse Genome Informatics, and major recombinase line projects into a unified dataset.