ReFRAME

ReFRAME: Drug Repurposing Compound Library for Neglected Diseases

ReFRAME aggregates 12,000 compounds with prior human use to enable systematic drug repurposing and accelerate identification of therapeutic candidates for neglected diseases.

Key Features:

• Curated Compound Library: Integrates 12,000 compounds from Clarivate Integrity, GVK Excelra GoStar, and Citeline Pharmaprojects, supplemented by patent mining of small molecules previously administered to humans.
• Human Safety Profiling: Prioritizes compounds with established clinical testing histories to facilitate rapid translational advancement.
• Chemical Diversity Coverage: Provides structurally diverse small molecules suitable for high-throughput phenotypic and target-based screening.

Scientific Applications:

• Antiparasitic Drug Discovery: Screening against Cryptosporidium spp. identified VB-201 and an analog of ASP-7962, both previously tested in humans and validated in animal models at clinically relevant doses.
• Neglected Tropical Disease Research: Enables rapid evaluation of approved or clinically tested compounds for alternative therapeutic indications.

Methodology:

Compounds with documented human administration were aggregated from commercial pharmacological databases and patent-mined sources to create a chemically diverse, clinically informed library. Systematic screening against disease-relevant biological targets or organisms supports identification of repurposable candidates with established safety data.