RegulomePA

RegulomePA: Transcriptional regulatory network database for Pseudomonas aeruginosa PAO1

RegulomePA catalogs transcriptional regulatory interactions among transcription factors (TFs), sigma factors (SFs), and target genes in Pseudomonas aeruginosa PAO1, providing a structured representation of its regulatory network.

Key Features:

• Regulatory Interaction Dataset: Contains 4,827 regulatory interactions across 2,831 nodes, covering 27.27% of TFs, 54.16% of SFs, and 50.8% of total genes in P. aeruginosa PAO1.
• Node Annotation: Provides gene description, nucleotide sequence, genome-strand position, interaction type (activation or repression), and supporting experimental evidence with references.
• Regulatory Circuit Analysis: Enables tracing of regulatory pathways and gene-specific interaction circuits within the network.
• Topological Analysis Tools: Supplies source code for structural and topological analysis of regulatory networks.

Scientific Applications:

• Gene Regulation Analysis: Supports investigation of transcriptional regulatory mechanisms in P. aeruginosa PAO1.
• Network Topology Studies: Enables analysis of structural properties, robustness, and dynamics of regulatory networks.
• Pathway Investigation: Facilitates exploration of regulatory circuits controlling biological pathways.

Methodology:

Curated database updated annually, integrating experimentally supported TF–SF–gene interactions and associated annotations.