reLATE

reLATE searches a database of 168,297 protein sequences from 8,826 animals, plants, and microorganisms to identify the closest matching sequence to a user-provided protein for comparative, homology, and functional analysis.

Key Features:

• Extensive Database: Contains 168,297 protein sequences from 8,826 animals, plants, and microorganisms for cross-species comparison.
• Sequence Matching: Performs sequence similarity searches that return the closest matching protein sequence to a user-provided query to support homology detection and functional annotation.
• Interoperability and Integration: Integrates with EMBL-EBI resources and databases to enable data interoperability across bioinformatics resources.
• Scalable Infrastructure: Operates on EMBL-EBI computational infrastructure, including substantial disk capacity and the Embassy Cloud, to support large-scale analyses.

Scientific Applications:

• Functional Genomics: Predicts protein function by identifying homologous sequences.
• Evolutionary Biology: Enables study of protein evolutionary relationships across species using comparative sequence matches.
• Protein Engineering: Informs protein design by revealing structural and functional similarities to existing sequences.

Methodology:

Compares user-provided protein sequences to the database using sequence alignment algorithms and leverages EMBL-EBI interoperability to integrate data from multiple sources.