AncestryGrapher

AncestryGrapher visualizes global and local ancestry inferences from RFMIX version 2 analyses, facilitating the exploration and reporting of ancestry patterns in human populations.

Key Features:

• Global Ancestry Visualization: The toolkit converts numerical output of RFMIX2 into graphical representations of per-individual ancestry components.
• Local Ancestry Visualization: The toolkit generates graphical representations of genetic ancestry along chromosomes.

Scientific Applications:

• Admixed Population Analysis: AncestryGrapher enables visualization of ancestry patterns in admixed human populations, as demonstrated with the North African Mozabite Berber population from the Human Genome Diversity Panel.
• Trait-Associated Locus Investigation: The toolkit supports exploration of local ancestry variation in genomic regions containing genes of interest, such as the MCM6 gene region on Chromosome 2 associated with lactase persistence.

Methodology:

AncestryGrapher processes numerical output from RFMIX version 2 and converts it into graphical representations.