RHIVDB

RHIVDB curates and integrates 1,651 HIV amino acid sequences and associated clinical patient data to support analysis of drug resistance and treatment outcomes for reverse transcriptase (RT), protease (PR), integrase (IN), and envelope protein (ENV).

Key Features:

• Extensive Sequence Repository: Contains 1,651 amino acid sequences covering reverse transcriptase (RT), protease (PR), integrase (IN), and envelope protein (ENV).
• Clinical Data Integration: Links sequence data with treatment history, CD4+ cell counts, and viral load measurements.
• User-Contributed Data Entry: Accepts direct submissions of HIV sequence and treatment information with expert verification prior to inclusion.
• Query Functionality: Enables detailed extraction of specific datasets for analyses ranging from basic virology to pharmacogenomics research.

Scientific Applications:

• Drug resistance analysis: Correlates amino acid variation in RT, PR, IN, and ENV with resistance phenotypes and treatment outcomes.
• Treatment efficacy and prediction: Identifies sequence patterns associated with patient responses to antiretroviral regimens to inform treatment decisions.
• Pharmacogenomics research: Supports studies linking viral genotypes to therapeutic responses and regimen optimization.
• Epidemiology and evolution: Enables investigation of prevalence, distribution, and evolutionary trends of HIV strains across populations.

Methodology:

Data curation and integration from published literature and direct researcher submissions, compilation of clinical data from patient records, and expert verification of new entries.