Ribocentre

Ribocentre compiles curated sequence, secondary and tertiary structural, and mechanistic data for 21 natural ribozyme families to support analysis of RNA catalysis.

Key Features:

• Sequence Data: Provides nucleotide sequences for ribozyme families to enable comparative sequence analysis.
• Structural Information: Contains annotated secondary and tertiary structural data for ribozymes to inform three-dimensional and folding analyses.
• Mechanistic Insights: Documents catalytic mechanisms and mechanistic details across ribozyme families.
• Timelines and Evolutionary Context: Includes timelines tracing discovery and knowledge development for each ribozyme family and contextual information on their evolutionary history.
• Applications: Summarizes reported applications of ribozymes in molecular design and biotechnology.
• Key Publications: Associates each ribozyme family with primary literature and significant publications.

Scientific Applications:

• Bioinformatics and molecular biology research: Supports investigations into ribozyme sequence, structure, and function.
• Sequence–structure–function analysis: Enables comparative analyses linking sequences to secondary/tertiary structures and catalytic function.
• Structural modeling and RNA design: Facilitates structural modeling and design of functional RNA structures.
• Synthetic biology and biotechnology: Informs repurposing of ribozyme modules for synthetic biology applications.
• Evolutionary and discovery timelines: Supports evolutionary studies and tracing of ribozyme discovery histories.

Methodology:

Systematic collection and organization of published sequence, secondary and tertiary structural, and mechanistic data integrated for 21 natural ribozyme families.