riboCIRC

riboCIRC: Repository and annotation platform for translatable circRNAs

riboCIRC compiles computationally predicted ribosome-associated circular RNAs (circRNAs) and manually curated experimentally verified translated circRNAs. It annotates circRNA-encoded peptides and provides cross-species conservation analysis to support translatome studies.

Key Features:

• Ribosome-Associated circRNA Repository: Hosts predicted ribosome-associated circRNAs and curated experimentally validated translated circRNAs.
• Cross-Species Conservation Analysis: Evaluates conservation of translatable circRNAs across multiple species for comparative analysis.
• De Novo Peptide Annotation: Systematically annotates putative circRNA-encoded peptides, including sequence, structural features, and inferred functions.
• Genome Context Visualization: Integrates genome browser-based visualization of context-specific occupant footprints of circRNAs.

Scientific Applications:

• Translatome and Comparative Genomics Studies: Supports exploration of translatable circRNAs, functional analysis of circRNA-encoded peptides, and evolutionary conservation assessment across species.

Methodology:

riboCIRC integrates computational prediction of ribosome-associated circRNAs with manual curation of experimentally validated translated circRNAs. It performs systematic annotation of circRNA-encoded peptides based on sequence, structural characteristics, and functional inference, and incorporates cross-species conservation analyses.