rMotif

rMotif performs de novo discovery and analysis of regulatory motifs, including transcription factor binding sites (TFBS), using a statistical framework optimized for high specificity and sensitivity.

Key Features:

• De Novo Motif Discovery: Identifies novel regulatory motifs and TFBS directly from genomic sequences using automated statistical algorithms.
• Motif Refinement and Expression Integration: Refines characterized or partially characterized motifs and integrates motif analysis with mRNA expression profiles to assess regulatory impact on gene expression.

Scientific Applications:

• Gene Regulation Analysis: Supports investigation of transcriptional regulation by detecting and characterizing regulatory elements and transcription factor binding sites.

Methodology:

rMotif applies a dedicated statistical background model and motif discovery algorithms to distinguish true regulatory elements from noise, enabling sensitive and specific identification and evaluation of transcription factor binding sites.