RNA helicase database

RNA helicase database provides integrated, curated sequence, structural, biochemical, and cellular function information on RNA helicases from model organisms including Escherichia coli, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, mouse, and human to support studies of RNA metabolism, structural biology, and evolutionary relationships.

Key Features:

• Comprehensive information: Curated data encompass sequences, structures, biochemical properties, and cellular functions of RNA helicases across multiple model organisms including Escherichia coli, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, mouse, and human.
• Structured classification: Entries are organized according to the classification of helicase superfamilies (SFs) and families to reflect relationships among RNA helicases.
• Centralized curated repository: A single resource consolidates curated annotations and data for comparative and functional analyses of RNA helicases.

Scientific Applications:

• RNA Metabolism: Supporting investigations into roles of RNA helicases in splicing, translation, degradation, and other RNA metabolic processes.
• Structural Biology: Enabling analysis of helicase structural features to infer mechanism and functional domains.
• Evolutionary Studies: Facilitating phylogenetic and comparative studies to assess evolutionary trends and functional conservation among RNA helicases.

Methodology:

Data are organized and annotated according to the classification of helicase superfamilies (SFs) and families and annotated to highlight phylogenetic relationships among RNA helicases.