RNAcanvas

RNAcanvas generates and edits RNA secondary structure diagrams by automatically arranging residues into stems and loops and enabling detailed structural annotation.

Key Features:

• Automated Secondary Structure Layout: Arranges residues into defined stems and loops to produce structured RNA diagrams suitable for large molecules.
• Tertiary Interaction Visualization: Depicts tertiary interactions with draggable curved connectors and supports Leontis-Westhof notation for non-canonical base pairs.
• Interactive Structure Editing: Provides real-time complementary sequence highlighting and motif search to assist identification of long-range and local structural features.

Scientific Applications:

• RNA Structural Analysis and Comparison: Supports manual refinement of predicted structures, identification of long-range tertiary interactions, de novo local structure analysis, and phylogenetic comparison of RNA architectures.

Methodology:

RNAcanvas applies automated layout algorithms to organize RNA residues into canonical secondary structure elements and enables interactive editing with motif detection and complementary sequence highlighting to facilitate structural analysis and annotation.