RNAEditingIndexer

RNAEditingIndexer (Alu Editing Index, AEI) quantifies adenosine-to-inosine (A-to-I) RNA editing from RNA sequencing data to estimate adenosine deaminase acting on RNA (ADAR) activity.

Key Features:

• A-to-I Editing Quantification: Computes a global RNA editing index focused on Alu elements to measure ADAR-mediated A-to-I editing levels.
• Genome-Wide Editing Profiling: Maps global editing patterns across large RNA-seq datasets to identify regulators and factors influencing ADAR activity and Alu editing.

Scientific Applications:

• ADAR Activity and RNA Editing Studies: Supports investigation of RNA editing dynamics in cancer, autoimmune disorders, and RNA engineering contexts.

Methodology:

AEI analyzes RNA sequencing data to calculate an index reflecting the proportion of A-to-I editing events within Alu elements, enabling systematic and comparative assessment of ADAR enzyme activity across samples.