RNAME

RNAME curates over 21,000 manually collected RNA modification enzymes from 456 species and provides enzyme identities, 3D structures, domains, subcellular localizations, and annotations for seven RNA modification types (adenosine-to-inosine (A-to-I), N1-methyladenosine (m1A), N6-methyladenosine (m6A), 5-methylcytidine (m5C), N7-methylguanosine (m7G), mRNA cap modification, and pseudouridine) to support studies of RNA modification biology.

Key Features:

• Extensive Enzyme Collection: Over 21,000 manually curated RNA modification enzymes from 456 species are included.
• Diverse Modification Coverage: Entries cover seven RNA modification types: adenosine-to-inosine (A-to-I), N1-methyladenosine (m1A), N6-methyladenosine (m6A), 5-methylcytidine (m5C), N7-methylguanosine (m7G), mRNA cap modification, and pseudouridine.
• Integrated Functional Data: Annotations include 3D structures, protein domains, subcellular localization, and biological function.
• Manual Curation and Experimental Evidence: Entries are manually curated and include experimentally validated data when available.

Scientific Applications:

• Identify and Characterize Enzymes: Detailed structure and functional annotations facilitate identification and characterization of novel RNA modification enzymes.
• Explore Biological Functions: Subcellular localization and functional annotations support inference of enzyme roles and pathways.
• Facilitate Comparative Studies: Coverage across 456 species enables comparative and evolutionary analyses of enzyme conservation and diversification.

Methodology:

Manual curation collected experimentally validated enzyme entries and integrated multidimensional data including 3D structures, domains, subcellular localization, and functional annotations.