RNAMST

RNAMST identifies homologs of predefined RNA structural motifs within large collections of RNA sequences, enabling analysis of RNA regulatory mechanisms including motifs implicated in post-translational regulation of gene expression.


Key Features:

  • Efficient data preprocessing: Implements strategic data preprocessing that enhances search efficiency on large RNA sequence datasets.
  • High-performance motif search: Integrates algorithms that deliver improved search speed and efficiency relative to earlier approaches.
  • Flexibility in analysis: Supports analysis of known functional RNA elements and putative structural motifs.

Scientific Applications:

  • Homolog discovery: Identification of homologous RNA structural motifs across large sequence collections.
  • Study of RNA regulatory mechanisms: Enables investigation of RNA-mediated regulation of gene expression, including roles in post-translational regulation.
  • Characterization of functional and putative motifs: Facilitates analysis and comparison of known functional RNA elements and candidate structural motifs.

Methodology:

Integration of advanced algorithms for data preprocessing and motif searching to achieve high accuracy and speed on large-scale RNA sequence databases.

Topics

Details

Tool Type:
web application
Added:
3/24/2017
Last Updated:
11/25/2024

Operations

Publications

Chang T, Huang H, Chuang T, Shien D, Horng J. RNAMST: efficient and flexible approach for identifying RNA structural homologs. Nucleic Acids Research. 2006;34(Web Server):W423-W428. doi:10.1093/nar/gkl231. PMID:16845040. PMCID:PMC1538813.