RNAStat

RNAStat computes statistical and geometric properties of RNA three-dimensional structures to support structural analysis and modeling.

Key Features:

• Secondary Structure and Motif Statistics: Analyzes structural properties including size and shape distributions and extracts secondary structure motifs using DSSR annotations, covering canonical and non-canonical base pairs, stems, and loop types.
• Geometric and Distance Analysis: Constructs local coordinate systems for each nucleotide to calculate base-pairing and stacking geometries and generates atom–atom distance distributions for development of distance-based statistical potentials.

Scientific Applications:

• RNA Structure Modeling and Evaluation: Provides statistical benchmarks and geometric parameters for guiding and validating RNA 3D structure prediction and refinement.

Methodology:

RNAstat processes non-redundant RNA 3D structure datasets, applies DSSR-based structural annotation, computes motif frequencies, geometric parameters, and interatomic distance distributions, and summarizes these features for statistical modeling applications.