RPRH

RPRH predicts and annotates potential regulatory roles of plant microRNAs (miRNAs) in human gene expression through cross-kingdom interaction analysis.

Key Features:

• Comprehensive Plant miRNA Dataset: Curates 10,414 plant miRNAs from 82 plant species to support cross-kingdom regulatory investigations.
• Functional Annotation Integration: Links plant miRNAs to 18,062 human-related annotation terms, including diseases, biological pathways, Gene Ontology (GO) categories, and drug associations.

Scientific Applications:

• Cross-Kingdom Gene Regulation Analysis: Supports investigation of plant miRNA-mediated modulation of human genes in disease, pathway, and therapeutic contexts.

Methodology:

RPRH integrates curated plant miRNA sequences with human functional annotation datasets to predict cross-kingdom regulatory associations and generate disease, pathway, Gene Ontology, and drug-related functional profiles for plant miRNAs.