RRE

RRE extracts non-coding regions associated with annotated genes from genomic datasets to enable analysis of regulatory elements and post-transcriptional control.


Key Features:

  • Non-Coding Region Extraction: Extracts gene upstream regions, 5′-untranslated regions (5′-UTRs), introns, 3′-untranslated regions (3′-UTRs), and downstream regions associated with annotated genes.
  • Integration with NCBI Datasets: Leverages annotated genomic datasets available at the National Center for Biotechnology Information (NCBI) for extraction targets.
  • Parser-Based Processing: Provides a parser for programmatic extraction of specified non-coding regions from annotated genomic data.

Scientific Applications:

  • Gene Regulation Studies: Enables identification and analysis of regulatory elements in upstream and untranslated regions that influence gene activity.
  • Expression Analysis: Supports analyses that correlate non-coding region features with gene expression patterns.
  • Functional Genomics: Facilitates characterization of non-coding elements in functional genomics investigations.
  • Alternative Splicing Investigation: Allows retrieval of intronic regions to investigate alternative splicing events.
  • Post-Transcriptional Control Studies: Enables examination of 5′-UTRs and 3′-UTRs for roles in post-transcriptional regulation.

Methodology:

Uses a parser to process annotated genomic datasets, including datasets from NCBI, to extract specified non-coding regions.

Topics

Details

Tool Type:
command-line tool
Operating Systems:
Linux, Windows
Programming Languages:
Java
Added:
12/18/2017
Last Updated:
12/10/2018

Operations

Publications

Lazzarato F, Franceschinis G, Botta M, Cordero F, Calogero RA. RRE: a tool for the extraction of non-coding regions surrounding annotated genes from genomic datasets. Bioinformatics. 2004;20(16):2848-2850. doi:10.1093/bioinformatics/bth287.

Documentation

Links