RSDB
RSDB compiles and organizes gene, chemical, and phenotype associations for rare skin diseases into integrated disease-specific networks to support therapeutic discovery.
Key Features:
- Disease-Specific Association Networks: Constructs pairwise gene–chemical–phenotype relationship networks linking disease mechanisms to potential therapeutic agents.
- Comprehensive Rare Disease Coverage: Includes 891 rare skin diseases defined by Orphanet and GARD with curated associated genes, phenotypes, chemicals, and their interconnections.
Scientific Applications:
- Drug Repurposing for Rare Skin Diseases: Identifies candidate therapeutic agents by analyzing integrated gene–chemical–phenotype networks.
Methodology:
RSDB integrates curated data from Orphanet and GARD to construct pairwise association networks among genes, chemicals, and phenotypes for each rare skin disease, enabling network-based identification of potential drug targets.
Topics
Details
- License:
- CC-BY-NC-SA-4.0
- Cost:
- Free of charge
- Tool Type:
- web application
- Operating Systems:
- Mac, Windows, Linux
- Added:
- 10/9/2022
- Last Updated:
- 11/24/2024
Operations
Publications
Kuo T, Wang P, Wang Y, Chang C, Chang C, Tseng YJ. RSDB: A rare skin disease database to link drugs with potential drug targets for rare skin diseases. Scientific Data. 2022;9(1). doi:10.1038/s41597-022-01654-2. PMID:36028515. PMCID:PMC9418253.
PMID: 36028515
PMCID: PMC9418253
Funding: - Ministry of Science and Technology, Taiwan: MOST109-2823-8-002-010-CV, MOST 109-2320-B-002-040-, MOST 110-2320-B-002-038-
- Ministry of Health and Welfare, Taiwan | Food and Drug Administration: MOHW110-FDA-D-114-000611
- National Taiwan University: NTU-CC-110L890803, NTU-110L8809