RSEG

RSEG identifies epigenomic domains from ChIP-Seq data by segmenting contiguous genomic regions marked by histone modifications.

Key Features:

• RSEG-Based Domain Segmentation: Applies the RSEG (Region Segmentation) method to delineate boundaries of broad histone modification domains rather than narrow peak regions.
• Control Sample Integration: Incorporates control datasets to detect and compare differential histone modification patterns between samples.

Scientific Applications:

• Epigenomic Domain Analysis: Maps and compares chromatin states associated with active transcription, poised genes, or heterochromatic silencing.

Methodology:

RSEG uses the RSEG segmentation algorithm to analyze ChIP-Seq read density profiles, defining contiguous regions of histone modification enrichment and enabling differential domain analysis with control samples.