RVdb

RVdb curates rhinoviruses (RVs) nucleotide and protein sequences, three-dimensional protein structures, and associated publications to support genetic characterization, serotyping, and epidemiological analysis.

Key Features:

• Extensive Data Repository: Contains 26,909 identified rhinovirus strains with related nucleotide and protein sequences, three-dimensional protein structures, and linked publications.
• Automatic Sequence Annotation: Performs automatic sequence annotation for deposited rhinovirus sequences.
• Multiple Sequence Alignment (MSA): Provides multiple sequence alignment functionality for comparative analyses of rhinovirus sequences.
• Phylogenetic Tree Construction: Enables phylogenetic tree construction from aligned rhinovirus sequences.
• BLAST Searches: Offers specialized BLAST searches tailored to rhinovirus sequences.
• Serotyping Pipeline: Implements an integrated serotyping pipeline covering 174 identified rhinovirus serotypes.

Scientific Applications:

• Epidemiological Surveillance: Monitoring the prevalence and spread of rhinovirus serotypes for public-health analyses.
• Genetic Characterization: Analyzing genetic diversity and mutation patterns of rhinoviruses.
• Vaccine and Antiviral Research: Supporting studies for vaccine development and antiviral evaluation using sequence and structural data.

Methodology:

Computational methods explicitly include automatic sequence annotation, multiple sequence alignment (MSA), phylogenetic tree construction, specialized BLAST searches, and an integrated serotyping pipeline.