SAbDab

SAbDab catalogs experimentally determined antibody structures from the Protein Data Bank (PDB) and provides curated structural annotations to support antibody and nanobody structural and therapeutic research.

Key Features:

• Comprehensive Repository: Aggregates experimentally determined antibody structures from the Protein Data Bank (PDB) into a centralized dataset.
• Consistent Annotation: Applies standardized, detailed annotations of structural features and metadata for each antibody entry.
• Weekly Updates: Incorporates newly deposited antibody structures and annotations on a weekly cadence.
• SAbDab-nano Sub-database: Maintains a dedicated collection of single-domain antibodies (nanobodies) derived from heavy chain-only antibodies.

Scientific Applications:

• Drug Development: Supports design and engineering of antibody-based therapeutics by providing structural information relevant to structure–function relationships.
• Basic Research: Enables studies of antibody diversity, evolution, and mechanisms of antigen recognition using curated structural data.
• Nanobody Research: Facilitates investigation of nanobody structure, stability, and application in diagnostic and therapeutic contexts.

Methodology:

SAbDab systematically collects antibody structures from the PDB, performs curation and consistent annotation of structural features and metadata, and organizes entries for querying and retrieval.