SarcoAtlas

SarcoAtlas maps gene expression patterns in skeletal muscle to characterize molecular mechanisms of aging and sarcopenia.

Key Features:

• Gene Expression Profiling: Integrates physiological data and extensive gene expression profiles from young and old mice to capture age-associated transcriptional changes.
• mTORC1 Signaling Focus: Highlights mTORC1-related molecular signatures, including links between mTORC1 activation, muscle hypertrophy, and organismal aging.
• Comparative Experimental Conditions: Enables comparison of gene expression across experimental perturbations explicitly including chronic mTORC1 inhibition with rapamycin and muscle fiber-specific genetic activation of mTORC1 in mouse models.
• Inter-muscle and Neuromuscular Junction Signatures: Identifies inter-muscle divergence and neuromuscular junction-associated gene expression changes relevant to sarcopenia.

Scientific Applications:

• Sarcopenia Research: Supports identification of primary molecular drivers of age-related muscle loss across muscles and age groups.
• Neuromuscular Junction Analysis: Facilitates analysis of neuromuscular junction-associated signatures implicated in mTORC1-driven muscle aging.
• Pharmacological and Genetic Studies: Supports investigation of effects from pharmacological inhibition (rapamycin) and genetic activation of mTORC1 on muscle gene expression during aging.

Methodology:

Comparative analysis of gene expression profiles across young and old mice and across experimental conditions including chronic rapamycin treatment and muscle fiber-specific genetic activation of mTORC1.