SARS2Mutant

SARS2Mutant analyzes amino acid substitutions in SARS-CoV-2 proteins to characterize mutation prevalence, temporal persistence, and natural selection signals relevant to viral evolution, host interactions, and phenotypic effects.

Key Features:

• Extensive Mutation Data: Compiles millions of high-quality, high-coverage complete protein sequences of SARS-CoV-2 for comprehensive mutation analysis.
• Search Capabilities: Allows querying amino acid substitution mutations by gene name, geographical zone, or comparative analysis.
• Mutated Sample Frequencies: Reports prevalence of specific amino acid substitutions across sequenced samples.
• Heat Maps: Visualizes mutated amino acid positions to identify mutation hotspots.
• Mutation Survivals: Tracks persistence of mutations over time to indicate temporal retention.
• Natural Selection Insights: Provides analyses indicative of natural selection pressures on substitutions.
• Substitution Details: Supplies substituted amino acid names, positions, and frequencies.

Scientific Applications:

• Vaccine development: Identifies conserved regions and mutation patterns to inform antigen selection for vaccine design.
• Therapeutic and drug development: Informs targeted therapeutic strategies and drug design by revealing mutation prevalence and persistence.
• Primer design: Guides primer selection by highlighting conserved and variable regions and their mutation frequencies.
• Evolutionary analysis: Elucidates SARS-CoV-2 evolutionary dynamics and natural selection signals affecting host interactions and phenotypes.

Methodology:

SARS2Mutant functions as a secondary database that extracts and analyzes primary genomic sequences from GISAID, which is updated daily with influenza virus genomes.