ScaPD

ScaPD catalogs scaffold proteins and their roles in signal transduction to support analysis of scaffold-mediated signaling networks.

Key Features:

• Content: Contains 273 scaffold proteins and annotations linking them to 1,118 associated signaling pathways.
• Data types: Integrates computationally predicted and experimentally validated scaffold–pathway associations.
• Manual curation: Entries are manually curated to ensure annotation quality.
• Biological focus: Centers exclusively on scaffold proteins and their roles in tethering signaling molecules and regulating pathway selectivity.

Scientific Applications:

• Signaling network analysis: Enables exploration of scaffold-mediated interactions within cellular signaling networks.
• Pathway regulation studies: Supports investigation of how scaffold proteins influence pathway selectivity and signaling outcomes.
• Disease and target research: Facilitates studies of disease mechanisms and identification of potential therapeutic targets involving scaffold proteins.
• Basic research: Serves as a reference for studying scaffold protein functions in cellular processes.

Methodology:

Integrates computationally predicted and experimentally validated data and applies manual curation of entries.