SCLD

SCLD provides an integrated database for stem cell lineage mapping by cataloging cell type-specific gene expression profiles, anatomical and developmental relationships, lineage maps, and differentiation protocols for human and mouse embryonic stem cells to support analysis and design of directed differentiation and developmental trajectory studies.

Key Features:

• Unified Resource: Consolidates cell type-specific gene expression profiles, anatomical and developmental relationships, and signals involved in progression from progenitor to target cell types into a single database.
• Lineage Maps: Presents lineage maps that illustrate endogenous development and directed differentiation processes in human and mouse embryonic stem cells.
• Protocol Design Support: Provides data on stem cell differentiation protocols to inform the design and refinement of experiments that mimic developmental processes.
• Data Sharing and Collaboration: Serves as a centralized repository for organizing and sharing data and annotations to resolve contentious relationships between cell types and within lineages.
• Marker Panel Identification: Assists identification of discriminating marker panels for distinguishing closely related cell types during differentiation studies.

Scientific Applications:

• Directed Differentiation Protocol Design: Supports design and refinement of directed differentiation protocols using lineage maps and protocol data.
• Lineage Analysis: Enables analysis of developmental trajectories and resolution of contentious relationships between cell types within lineages.
• Marker Selection: Facilitates selection of discriminating marker panels for cell type identification and characterization.
• Regenerative Medicine Development: Informs strategies for generating specific cell types from stem cells for therapeutic applications.

Methodology:

Integrates gene expression profiles, anatomical and developmental relationships, lineage maps, and differentiation protocols into a cohesive database.