scTWAS Atlas

scTWAS Atlas catalogs single-cell transcriptome-wide association study (scTWAS) associations and integrates literature curation with data analysis to enable exploration of genetic regulatory mechanisms at the cellular level.

Key Features:

• Comprehensive Association Database: scTWAS Atlas amasses 2,765,211 associations encompassing 34 traits, 30 cell types, 9 cell conditions and 16,470 genes.
• Interactive Knowledge Graph: The database integrates single-cell expression quantitative trait loci (sc-eQTL) and scTWAS associations to build a multi-omics level regulatory network at the cellular level.
• Cross-Cell-Type Analysis: scTWAS Atlas highlights cell-type-specific and shared TWAS genes across different cell types.

Scientific Applications:

• Cell-Type Heterogeneity Interpretation: scTWAS Atlas addresses the challenge of interpreting cell-type heterogeneity in traditional transcriptome-wide association study (TWAS) results by enabling TWAS analysis at the cellular level.
• Gene-Trait Association Identification: The database supports identification of gene-trait associations with higher precision through single-cell transcriptome-wide association studies.
• Genetic Regulatory Mechanism Exploration: scTWAS Atlas facilitates investigation of genetic regulatory mechanisms at the cellular level and the role of various cell types in biological processes.

Methodology:

scTWAS Atlas integrates literature curation and data analysis to compile scTWAS associations.