SEGMEnT_HPC

SEGMEnT_HPC performs cell-for-cell anatomic-scale simulations of intestinal pathophysiology using high-performance computing (HPC) and histological data to integrate gut epithelial and organ-level mechanisms.

Key Features:

• High-performance computing (HPC): Uses HPC resources to enable large-scale anatomic simulations.
• Massively parallel computation: Employs massively parallel computation to scale simulations to anatomic domains.
• Cell-for-cell anatomic-scale simulation: Simulates individual cells across whole-anatomic structures of the intestinal tract.
• SEGMEnT model extension: Extends the SEGMEnT gut epithelium simulation model to anatomic scales.
• Multiscale spatial modeling: Represents pathophysiological processes across microscopic cellular to macroscopic and organ-level spatial scales.
• Histology-based modeling: Incorporates histological data for representation of disease diagnosis and staging.

Scientific Applications:

• Ileal pouchitis simulation: Simulates the pathogenesis and abnormal tissue structures of ileal pouchitis in patients post-surgery for ulcerative colitis.
• Intestinal tract pathophysiology: Models complex intestinal pathophysiological processes to inform diagnosis and therapeutic strategies.
• Organ-level disease representation: Represents organ-level structural changes that emerge from cellular abnormalities.

Methodology:

Extends the SEGMEnT gut epithelium model via massively parallel computation on high-performance computing (HPC) systems to perform cell-for-cell anatomic-scale simulations across multiple spatial scales.