SEPIA

SEPIA performs quantitative susceptibility mapping (QSM) of MRI phase images to quantify susceptibility sources and to distinguish paramagnetic from diamagnetic tissue contributions.

Key Features:

• QSM processing: Processes MRI phase images to compute quantitative susceptibility maps (QSM).
• Paramagnetic/diamagnetic separation: Enables quantification and separation of paramagnetic and diamagnetic susceptibility sources, including hemorrhage and calcification.
• Integration of QSM toolboxes: Integrates multiple QSM toolboxes to assemble alternative inversion and reconstruction methods.
• Custom pipeline construction: Supports construction and execution of customized QSM processing pipelines.
• Algorithm parameter control: Exposes algorithm parameter control across integrated QSM methods.
• Extendable framework: Provides an extendable framework for incorporation of additional algorithms and methods.

Scientific Applications:

• Iron quantification: Quantification of iron deposition via susceptibility measurements.
• Hemorrhage versus calcification: Differentiation of hemorrhage (paramagnetic) from calcification (diamagnetic) based on susceptibility contrast.
• Method comparison and optimization: Comparative evaluation and optimization of QSM inversion and reconstruction methods.
• Neuroimaging studies: Application in clinical and research neuroimaging studies requiring susceptibility mapping.

Methodology:

Integration and orchestration of existing QSM toolboxes to construct and execute customized processing pipelines with algorithm parameter control and an extendable framework for adding new methods.