SEQPower

SEQPower performs power analysis and sample size estimation for sequence-based rare variant (RV) association studies by modeling the allelic architecture of complex diseases.

Key Features:

• Power Analysis and Sample Size Estimation: Performs power analysis and sample size estimation for sequence-based rare variant (RV) association studies by modeling allelic architectures of complex diseases.
• Diverse Genetic and Phenotypic Models: Supports a variety of genetic variant models and disease phenotype frameworks to simulate different allelic and phenotypic scenarios.
• Study Design Optimization: Enables selection of sample sizes and statistical tests tailored to sequence-based association studies to optimize study design.
• Comparison and Validation Platform: Provides a platform to compare, validate, and assess novel and existing rare variant (RV) association methods fairly within genetic epidemiology.

Scientific Applications:

• Genetic Epidemiology: Designing and powering sequence-based rare variant association studies to investigate the genetic basis of complex traits and diseases involving rare variants and disease phenotypes.

Methodology:

Uses advanced statistical methods to model allelic architecture and simulates genetic and phenotypic scenarios to evaluate the performance of different RV association methods.