SGRP Blast Server

SGRP Blast Server provides BLAST-based sequence alignment and retrieval across genomes of over seventy Saccharomyces cerevisiae and Saccharomyces paradoxus isolates to support comparative genomic and evolutionary analyses.

Key Features:

• Extensive Genomic Coverage: Provides genomic data from over seventy S. cerevisiae and S. paradoxus isolates with one- to fourfold greater coverage than previously available datasets.
• BLAST Integration: Uses BLAST (Basic Local Alignment Search Tool) for sequence alignment and retrieval against this dataset.
• Sequence Retrieval Option: Enables retrieval of specific genomic sequences for targeted analysis of genes or regions.

Scientific Applications:

• Genome Evolution Studies: Enables examination of adaptation and phenotypic variation by comparing genomes across multiple isolates.
• Population Structure Analysis: Facilitates analysis of population structure and geographic differentiation in S. cerevisiae and S. paradoxus.
• Phenotypic Correlation Studies: Supports analysis of correlations between phenotypic traits and genome-wide phylogenetic relationships.

Methodology:

Applies BLAST for sequence alignment and retrieval; analyzes gene content differences, single nucleotide polymorphisms (SNPs), insertions and deletions, copy number variations, and transposable elements; and maps genome-wide phylogenetic relationships.