sgTarget

sgTarget facilitates selection and prioritization of candidate proteins for structural determination from genomic and gene/protein sequences.

Key Features:

• Sequence Annotation and Family Identification: Annotates submitted gene or protein sequences and identifies sequence families that lack homologues with known structures.
• Physicochemical Property Analysis: Computes a comprehensive set of physicochemical properties relevant to expression, solubility, and crystallization potential.
• Customizable Target Selection: Processes entire datasets and provides summaries for individual sequences and for the dataset as a whole to support iterative target prioritization.

Scientific Applications:

• Novel Fold Discovery: Identifies proteins without known structural homologues to aid discovery of new protein folds.
• Target Prioritization for Structure Determination: Ranks and selects viable candidates for expression, solubility testing, and crystallization based on computed properties.
• Structural Genomics from Genomes: Leverages genomic and gene/protein sequence data to expand structural genomics target selection.

Methodology:

Performs sequence annotation, family identification, homology searches, and analysis of physicochemical attributes.